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Author

Edward B. Lee

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Open access Sep 2026

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph

Tau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy (cryo-EM) data from brain-derived chronic traumatic encephalopathy (CTE) tau filaments deposited in EMPIAR-10313. We resolv...

Ryohei Watanabe, Edward B. Lee · 0 citations
Open access Aug 2026

Repositioning of polyubiquitin alters the pathologic tau filament structure.

It is found that polyubiquitinated tau filaments from Alzheimer disease and vacuolar tauopathy human brain tissue exhibit distinct seeding patterns in mice, in association with differences in tau filament ultrastructure determined by cryo-electron microscopy.

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich et al. · 0 citations

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