T cell impairment, marked by immune checkpoint expression and exhaustion, could serve as a functional biomarker for S. aureus PJI disease outcome, and therapeutic blockade of checkpoint proteins may represent a potential strategy to improve outcomes following surgery.
Motoo Saito, Katya A. McDonald, Alexander Grier et al.· Communications Medicine· 0 citations
Staphylococcus aureus is the leading cause of implant-associated osteomyelitis. It has a high recurrence rate, a low post-operative cure rate, and can lead to sepsis, multiorgan failure, and death. This indicates a need for future innovation in therapeutics and vaccines. With our humanized mouse model, we aimed t...
Katya A. McDonald, Motoo Saito, Himanshu Meghwani et al.· Journal of Immunology· 0 citations
These platforms include bioceramics, metal-based scaffolds, hydrogels, nanoparticles, nanoparticles, and microsphere systems that represent the evolving research landscape, shifting away from just symptom alleviation and towards targeted disease-modifying therapies, including osteoimmunomodulation.
Sarah Bergren, Hannah Shelby, J. Wier et al.· Biomedicines· 0 citations
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