Open access
Oct 2026
CAR-engineered microglia harness phagocytosis to target brain tumor in organoid models.
Glioblastoma (GBM) is among the most aggressive and lethal brain tumors, and standard treatment offers only modest survival benefits. Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematologic cancers, but its efficacy in GBM remains limited. Here we develop a CAR-engineered microglia (...
Museog Choe, W. Yang, Bilal Cakir et al.
· Cell Reports · 0 citations