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Author

Eiji Morita

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Open access Sep 2026

A NanoLuc-Based Protease Biosensor for Highly Sensitive Detection of Intracellular Protease Activity: Applications to Apoptosis and Coronavirus Infection

FlipNanoLuc is a highly sensitive protease biosensor based on the β-strand-flipping principle of NanoLuc luciferase, which is derived from Oplophorus gracilirostris. In the inactive configuration, one β-strand of NanoLuc is repositioned, thereby suppressing luciferase activity. Upon cleavage of the embedded protease re...

Masashi Arakawa, Eiji Morita · 0 citations

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