Author

Elena Grassi

3 papers indexed here

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Open access Oct 2026

A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration

Spinella et al. linked a Crohn’s disease risk allele regulating SKAP2 expression to T lymphocyte function. SKAP2 enhances cell adhesion while suppressing migration. Sustained TCR signaling triggers its proteolytic cleavage to enable migration. Overall, genetic alteration of SKAP2 levels drives T cell dysfunction and pr...

Mara Cetty Spinella, Francesco Gualdrini, Cristina Leoni et al. · Journal of Experimental Medi... · 0 citations

Open access Oct 2026

Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities.

Microsatellite-stable (MSS) colorectal cancer (CRC) is a molecularly complex and clinically challenging disease subtype, lacking effective targeted therapies. Leveraging multiomic data from ∼2,000 tumor samples (including 316MSS CRCs not previously profiled) representing ∼4,500 molecular profiles and 195,246 single cel...

A. Sadanandam, A. O'Farrell, I. Miller et al. · Cancer Cell · 1 citation

Open access Aug 2026

Inference of lineage hierarchies, growth, and drug response mechanisms in cancer cell populations without tracking.

Lineage hierarchies and plasticity regulate development and tissue homeostasis, while diverted lineage dynamics and aberrant phenotypic plasticity are among the causes of incomplete drug response and resistance in cancer. Knowing the dynamics of phenotypically heterogeneous populations is therefore central to understan...

Andrea Piras, F. Galvagno, Letizia Pizzini et al. · Cell Reports Methods · 0 citations