Author

Elena J. Tucker

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Review Open access Aug 2026

The role of mitochondrial dysfunction and genetics in female infertility and premature ovarian insufficiency.

BACKGROUND Female infertility occurs in ∼37% of infertile couples, while premature ovarian insufficiency (POI) impacts 1-3.7% of women under the age of 40. POI is clinically heterogeneous, with various genetic pathways associated with its pathogenesis. Mitochondrial diseases (MDs) are a broad group of clinically hetero...

Brianna L Kline, A. Compton, A. E. Frazier et al. · Human Reproduction Update · 0 citations

Review Open access Jul 2026

Safeguarding the development of offspring: the role of genetic integrity of the maternal germline.

The role of maternal effect genes (MEGs) in orchestrating early zygotic development is explored, detailing their functions in epigenetic regulation, mitochondrial dynamics, DNA repair, and cell division, and the first comprehensive catalogue of associated diseases is presented.

Xuebi Cai, K. Hutt, Amy L. Winship et al. · Endocrine reviews · 0 citations