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Author

Elena Marcello

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Review Open access Aug 2026

GLP-1 receptor agonists for Alzheimer’s disease: Lessons from trials and translational challenges

Alzheimer’s disease (AD) is a multifactorial disorder that requires combined therapeutic strategies beyond amyloid clearance. Although GLP-1 receptor agonists show strong mechanistic rationale and supportive epidemiological signals for neuroprotection, large randomized trials in symptomatic AD have yielded negative cli...

R. Stringhi, Alessandro Padovani, Elena Marcello · 0 citations
Open access Jul 2026

Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons

Mapping the spatiotemporal dynamics of PS exposure in mature hippocampal neurons under physiological and pathological conditions using time-lapse imaging reveals specific PS externalization hotspots at dendritic branching points, presenting a potential target for neuroprotective strategies in neurodegeneration.

Adriana Schneider, Alexandra B. Merkel, Nunzio Perta et al. · 0 citations

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