Author

Elias S. J. Arnér

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Open access Oct 2026

Extracellular GPX3 drives insulin receptor expression in adipose tissue independent of its peroxidase activity

Obesity-associated insulin resistance is driven in part by adipose tissue dysfunction and oxidative stress, yet the role of extracellular mechanisms in modulating insulin signaling remains poorly understood. Here, we show that extracellular Glutathione Peroxidase 3 (GPX3) enhances adipocyte insulin sensitivity and func...

R. Hauffe, M. González, S. Chopra et al. · bioRxiv · 0 citations

Review Open access Oct 2026

Integrated Roles of The Thioredoxin-related Protein of 14 kDa, TRP14, in Sulfur Amino Acid Metabolism, Protein Posttranslational Modifications and Signaling.

Thioredoxins and glutaredoxins are typically small "redoxin" proteins that play predominant roles in shuttling reducing power from the primary nicotinamide adenine dinucleotide phosphate (NADPH)-dependent disulfide reductases, thioredoxin reductase (TrxR, TXNRD) and glutathione disulfide-reductase (Gsr) to diverse down...

Juan Sastre, A. J. Simmons, A. Miranda-Vizuete et al. · Free Radical Biology & Medic... · 0 citations