Open access
Aug 2026
Glyoxalase 1 Regulates Methylglyoxal-Derived Nucleic Acid Adduct Burden
Increased metabolic stress associated with diabetes and cancer increases the level of reactive dicarbonyl molecules that covalently modify nucleic acids. Methylglyoxal (MG), one of the most abundant endogenous dicarbonyl electrophiles, reacts with guanine bases in DNA and RNA to form covalent adducts that compromise...
Alana Battad, Francisco Núñez, S. Lai et al.
· Chemical Research in Toxicol... · 0 citations