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Elizabeth desRanleau

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Open access Jul 2026

A C. elegans model for functional analysis of conserved ADPKD variants in cilia, extracellular vesicles, and sensory signaling.

It is concluded that PC2C331S may perturb protein stability and/or polycystin complex formation prior to ciliary/EV trafficking and a C. elegans pipeline for mechanistic classification of conserved ADPKD-associated missense variants is established.

Juan Wang, Carlos Nava Cruz, Jonathon D. Walsh et al. · 0 citations