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Elizabeth Rubin

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Review Open access Jul 2026

Conversational Artificial Intelligence and Neuropsychiatric Risk: A Narrative Review and Case-Based Synthesis Proposing a Delusional Feedback Loop

A targeted literature review and case-based analysis of 35 reported instances in which interactions with generative AI systems were temporally associated with the onset or worsening of psychotic symptoms revealed a conceptual hypothesis termed the delusional feedback loop, in which AI-generated responses iteratively validate distorted beliefs, contributing to their persistence and escalation.

N. Abesadze, Abigale Fernandes, Elizabeth Rubin · 0 citations