Open access
Oct 2026
Further Development of Dual-Target Mu Opioid Receptor-Dopamine D3 Receptor (MOR-D3R) Ligands as Novel Therapeutics
A behavioral profile for (R)-LS01–64 is revealed characterized by acute enhancement of brain reward function but reduced reinforcing and conditioned rewarding effects compared with TRV734 and (R)-LS02–14, as potent MOR partial agonists and D3R antagonists.
K. Jahan, A. Bonifazi, Julie Sanchez et al.
· ACS Pharmacology & Trans... · 0 citations