Enantioselective Hydroarylation via Chiral Transient Directing Groups: Access to Chiral Benzo-Fused Heterocycles with Collaborative Enantiomeric Control.
A general and practical enantioselective C-H activation/hydroarylation enabled by chiral transient directing groups (cTDGs) and ruthenium η-arene catalysts is reported, providing efficient access to benzo-fused six-membered heterocycles, including chiral chromanes, xanthenes, and related frameworks. It represents a rar...