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Author

Ellissa Krekeler

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Open access Sep 2026

Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis

Overall, the findings show that RNF216 and OTUD4 balance rates of protein synthesis and degradation and suggest GHS-related mutations in RNF216 or OTUD4 may offset this balance, triggering neurodegeneration.

Wei Wei, Ruochuan Liu, Jing Zhang et al. · 0 citations
Open access Sep 2026

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.

Alkylation chemotherapy is commonly used against tumors such as glioblastoma, yet resistance often develops through downregulation of mismatch repair (MMR). Previous work has established that loss of MMR prevents the excision of the thymine-containing strand across O 6meG-T mismatches, thereby avoiding the futile repai...

Mohamed E. Ashour, Ellissa Krekeler, Monika Chandan Bhowmik et al. · 0 citations

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