Early Eye Organoids Demonstrate Cadherin and Semaphorin Disruption in PAX6-Related Aniridia
The paired box transcription factor PAX6 is a master regulator of eye development. Pathogenic PAX6 variants predominantly cause aniridia, resulting in a wide range of ocular anomalies affecting both the anterior and posterior segments of the eye. However, a detailed examination of the transcriptomic alterations that oc...