Open access
Sep 2026
A Synthetic, Small Molecule, Allosteric Inhibitor of Human Factor XIa for Thrombosis.
Only a handful of anticoagulants have reached the clinic to treat and prevent thrombotic episodes in the millions of patients suffering from cardiovascular, cancer, viral (COVID-19) and metabolic diseases. In this work, we report the discovery, chemical synthesis, mechanistic biochemistry, pharmacology, and toxicology...
Chiranjeev Sharma, Rama Gunta, Sridhar R. Iyer et al.
· Blood Advances · 0 citations