Author

Elshimaa M. N. Abdelhafez

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Open access Nov 2026

Design, click synthesis, and biological evaluation of novel uracil-1,2,3-triazole hybrids as dual EGFR/CDK1 inhibitors: antiproliferative activity, mechanistic insights, and in silico studies

A novel series of uracil–1,2,3-triazole hybrids was designed, synthesized, and evaluated as dual EGFR/CDK1 inhibitors to target cancer cell proliferation and survival. Synthesis was initiated via the nucleophilic substitution of 2-chloro-N-(1,3-dimethyl-2,6-dioxo-pyrimidin-4-yl)acetamide (3) with sodium azide, yielding...

Asmaa H. Mohamed, Ashraf A. Aly, Elshimaa M. N. Abdelhafez et al. · RSC Advances · 0 citations

Review Open access Oct 2026

1,3,4-Oxadiazole–sulfonamide hybrids: recent advances in biological activities, structure–activity relationships, and therapeutic applications

The available evidence demonstrates the remarkable therapeutic versatility of 1,3,4-oxadiazole–sulfonamide hybrids and supports their continued exploration as promising scaffolds for future drug discovery and development.

Alshaimaa Hosney, Elshimaa M. N. Abdelhafez, Mamdouh F. A. Mohamed · RSC Advances · 0 citations