Open access
Jul 2026
Are Native Conformations of Proteins Retained Throughout Laser Ablation Capture?
Combining ion mobility-mass spectrometry (IM-MS) with laser ablation (LA) is an attractive approach for characterizing protein higher-order structure in native ambient MS (NAMS). Recently, we demonstrated that proteins ablated from native deposits are detected in their native higher-order structure. However, it remains...
Neda Feizi, Blessing C Egbejiogu, Kelcey B. Hines et al.
· Analytical Chemistry · 0 citations