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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Emad Tajkhorshid

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Open access Oct 2026

Conformational switch of NPC1 epitomizes a lumen-to-membrane alternating access model for nonpolar substrates.

Niemann-Pick disease type C (NPC) arises from failure of the NPC1 and/or NPC2 proteins to mobilize lysosomal cholesterol, yet the mechanism by which the complex drives sterol translocation lacks a thorough understanding. Here, we capture an NPC1-NPC2 complex conformation at lysosomal pH using a bis-sterol ligand (JM046...

Xue-Lan Wu, Sepehr Dehghani-Ghahnaviyeh, A. Rasouli et al. · 0 citations
Open access Jul 2026

Substrate biasing in UCHL5 proteoforms

The molecular basis for substrate selectivity in a deubiquitinating enzyme is described, an unexplored area in the enzymes that counteract ubiquitin E3 ligases, an unexplored area in the enzymes that counteract ubiquitin E3 ligases.

Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai et al. · 0 citations
Open access Jul 2026

Evolution of N‐terminal mechanical lability as a determinant for Type III secretion

Using atomic‐force‐microscopy‐based force spectroscopy, it is shown that effector NleC is mechanically labile and mechanically compliant, supporting the notion that mechanical lability is an evolved, structurally encoded feature underlying effector secretion.

Katherine E. DaPron, Alexandre M. Plastow, Morgan R. Fink et al. · 0 citations

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