Modulating TDP-43 Protein Aggregation Directly and Indirectly in C. Elegans
Neurodegenerative diseases (NDs) are progressive disorders characterized by neuronal loss, and their prevalence is rising with an aging global population. Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which TDP-43 protein forms toxic aggregates in more than 95% of cases. Current FDA-approved AL...