Lupus nephritis (LN) is initiated by immune-complex deposition, complement activation, and inflammation, but these mechanisms do not fully explain why some glomerular lesions resolve whereas others progress to podocyte depletion, glomerulosclerosis, and fibrosis. We present a conceptual spatial framework in which grade...
R. S. Hamad, Elsayed A. Elmorsy, A. El-kott et al.· Tissue & Cell· 0 citations
Lysosomal membrane failure contributes to cellular injury by disrupting degradation, metabolism, immune signaling, and compartmental integrity, yet the physical principles that determine whether a mechanically loaded lysosome adapts or ruptures remain incompletely resolved. This review integrates biophysical and molecu...
R. S. Hamad, A. El-kott, Sally Negm et al.· Progress in Biophysics and M...· 0 citations
Serum levels of kynurenine, NLRP3, and 8-OHdG are all markedly increased in depression and together offer helpful diagnostic data, implying potential utility as complementary biological markers for diagnosing depression and describing its underlying pathophysiology, notwithstanding their modest relationships with sympt...
H. Alrasheed, A. A. El-Hanafy, Mostafa M. Bahaa et al.· Scientific Reports· 0 citations
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