Emily A. Ouellette

Deciphering the Structure−Activity Relationships Underpinning the Linkerology of Bivalent EGFR Inhibitors

Linking small molecules that bind adjacent sites on a target is a promising strategy for developing compounds with tight binding affinities. ATP-allosteric bivalent inhibitors (AABIs) of the epidermal growth factor receptor (EGFR) have provided new insights into efficient linker design where large potency gains can b...