Nov 2025
Vitamin B12 alleviates spliceosomopathy via phospholipid remodeling
Spliceosomal dysfunction profoundly impacts cellular metabolism, yet mechanistic links between RNA splicing defects and metabolic rewiring remain limited. Here, we investigate Verheij syndrome (VRJS), a rare disease caused by mutations in the core splicing factor PUF60. Using a Caenorhabditis elegans model, human cell...
A. Antebi, Wenming Huang, Jonathan Kölschbach et al.
· Research Square · 0 citations