Ewing sarcoma is an aggressive bone malignancy occurring in children, adolescents, and young adults. Most cases are caused by expression of the fusion oncoprotein EWSR1::FLI1, which contains the low complexity domain (LCD) of EWSR1 and the DNA-binding domain (DBD) of FLI1. Previous genomic studies indicate EWSR1::FLI1...
Ruo-Wen Chen, R. Zhou, E. J. Tokarsky et al.· bioRxiv· 0 citations
Ewing sarcoma is a rare and aggressive pediatric cancer caused by a translocation-derived fusion oncoprotein that fuses the N-terminal low complexity domain (LCD) of a FET protein (FUS, EWSR1, or TAF15) with the C-terminal portion of an ETS transcription factor from the ERG or PEA3 subfamilies. These fusion oncoprote...
Ruo-Wen Chen, R. Zhou, E. J. Tokarsky et al.· Cancer Research· 0 citations
Ewing Sarcoma is defined by its hallmark mutation, a t(11;22)q24;q12) translocation which results in fusion of the EWSR1 and FLI1 genes. The fusion product, EWSR1::FLI1, contains the N-terminal low complexity domain (LCD) of EWSR1 and the DNA-binding Domain (DBD) of FLI1. EWSR1::FLI1 binds at microsatellites (µsats),...
Caleb J. Frye, R. Zhou, Lexis R. Rice et al.· Cancer Research· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
