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Emily R. Turpin

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Open access Oct 2026

Female sex accelerates retinal neurodegeneration in Herc3-deficient mice

Retinal degeneration involves mechanisms common to other neurodegenerative diseases, including mitochondrial dysfunction, inflammation, and impaired proteostasis via the ubiquitin-proteasome system (UPS). Although sex hormones modulate these pathways, the molecular basis of this sexual dimorphism remains poorly...

Dogan Can Kirman, Ashley A. Rowe, Ashwani Kumar et al. · 0 citations

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