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Author

Emma U. Hammarlund

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Open access Sep 2026

Hypoxia-Responsive HIF-1α-Dependent RhoA Signaling Promotes Motility and Aerotaxis in Polyaneuploid PC3 Cancer Cells with Increased Nuclear Rounding.

Most cancer deaths result from metastasis, yet only a subset of tumor cells can complete this process. Polyaneuploid cancer cells (PACCs), which arise via endoreplication under stressors such as hypoxia, are implicated as metastatic drivers, but how they acquire this capacity remains unclear. Here, we show that under e...

Noreen Hosny, Shengkai Li, Robert Gatenby et al. · 0 citations
Review Open access Aug 2026

Translational insights and clinical challenges of targeting cancer stem cells

Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durability of cancer treatment. However, translation o...

Mehreen Ahmed, A. Al-haidari, S. Agarwal et al. · 0 citations

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