Author

Emmanuel Ortega-Robles

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Review Open access Sep 2026

Dopamine Metabolism as a Chemically Constrained Network: Structural Regulation, Redox Liability and Dopaminergic Vulnerability in Parkinson’s Disease

Dopamine metabolism lies at the intersection of enzymatic catalysis, redox chemistry and cellular compartmentalisation, forming a tightly regulated network that sustains neurotransmission while limiting intrinsic chemical reactivity. In catecholaminergic neurons, dopamine is both an essential signalling molecule and a...

Emmanuel Ortega-Robles, Magdalena Guerra-Crespo, Oscar Arias-Carrión · Medical Science · 0 citations

Review Open access Aug 2026

Mitochondrial resilience: a convergent framework for pathogenesis and neuroprotection in Parkinson’s disease

This integrated framework reframes PD as a disorder of impaired cellular maintenance rather than solely a consequence of late-stage degenerative processes, and provides a translational shift from mechanism-based biomarkers to early detection of mitochondrial failure and supports therapeutic strategies aimed at restorin...

Oscar Arias-Carrión, Magdalena Guerra-Crespo, L. O. Soto-Rojas et al. · Frontiers in Pharmacology · 0 citations

Review Open access Aug 2026

LRRK2: Molecular Mechanisms in Parkinson’s Disease

Structural, biochemical, and cellular evidence is integrated to advance a unifying hypothesis that PD-associated LRRK2 dysfunction arises from maladaptive stabilization of specific conformational and spatial states within a membrane-responsive signalling network, leading to persistent misregulation of Rab-dependent tra...

Oscar Arias-Carrión, Magdalena Guerra-Crespo, Daniel Ortuño-Sahagún et al. · International Journal of Mol... · 0 citations