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Author

Emrah Düzel

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Open access Sep 2026

Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults

The role of physical fitness in cognitive reserve and brain maintenance remains unclear. We investigated the associations of muscular and aerobic fitness (VO2max) with markers of brain health and cognition in 353 cognitively unimpaired older adults (mean age = 72.77 ±  7.95 years; 177 females). Muscular fitness compris...

S. Schwarck, N. Behrenbruch, B. Schumann-Werner et al. · 0 citations
Open access Oct 2026

Amyloid, p‐tau, neurofilament light, and α‐synuclein cerebrospinal fluid biomarkers across Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease

Amyloid and tau positivity in DLB were associated with worse global cognitive outcomes, but not with motor performance, and NfL levels were elevated across diseases, and total α‐synuclein levels were associated with tau positivity.

Marianna Rizzo, C. Teunissen, H. Zetterberg et al. · 0 citations
Open access Sep 2026

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

J. Thomassen, H. Leonard, Brittany Ulms et al. · 0 citations
Open access Aug 2026

Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults

Differential associations of age and AD pathology with mesoscale MTL-connectivity patterns show differential associations of age and AD pathology with mesoscale MTL-connectivity patterns, which may support memory function in the short term while contributing to subsequent memory decline.

Larissa Fischer, N. Vockert, Joseph Höpker Fernandes et al. · 0 citations
Open access Jul 2026

Disruption of temporo-parietal network in Alzheimer’s disease and its association with memory impairment

Findings indicate that temporo-parietal connectivity is associated with both AD molecular pathology and, for a subset of connections, with memory performance, which may provide a link between synaptic pathology and cognitive outcomes.

Yanin Suksangkharn, B. Schott, P. Zeidman et al. · 0 citations
Open access Jul 2026

Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales

WMH confluence is introduced as a reproducible, automated, and fine-grained measure of lesion spatial organisation that provides complementary information about morphological WMH severity beyond volume and is an alternative to visual rating scales.

Tatjana Schmidt, Robert Salzmann, M. Montagnese et al. · 0 citations

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