Synthesis of Chalcone‐Sulfonamide Hybrids as Antibacterial, Antioxidant, and Anti‐Inflammatory Agents With Comprehensive In Silico and ADMET Profiling
Chalcone‐sulfonamide hybrids (12a–h) were synthesized via Claisen–Schmidt condensation in good yields (64%–83%) and confirmed by NMR spectroscopy. The compounds exhibited moderate to good antibacterial activity against Gram‐negative (Escherichia coli, Pseudomonas aeruginosa) and Gram‐positive (Staphylococcus aureus, St...