Open access
Jul 2026
Mitochondrial metabolism and epigenetic crosstalk drive SASP
Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP)1. Cytosolic mitochondrial nucleic acids activate innate immune signalling to initiate this inflammatory programme2,3. Here we show that mitochondrial metabolism provides a second layer of control that enables...
Hélène Martini, Jodie Birch, Francisco D M Marques et al.
· Nature · 3 citations