Methylglyoxal as a Convergent Mediator of Diabetic Complications: Generation, Protein Targets, Tissue Distribution, and Therapeutic Reduction—A Clinically Oriented Mechanistic Synthesis
Methylglyoxal (MGO), a highly reactive 1,2-dicarbonyl, is generated by all three principal pathways of advanced glycation end product (AGE) synthesis in type 2 diabetes mellitus (T2DM)—the Hodge, Namiki, and Wolff pathways—and by the non-enzymatic degradation of glycolytic triose phosphates. It is the principal substra...