Open access
Sep 2026
USP-48 enables insulin-mediated longevity and modulates the mitochondrial stress response.
The mitochondrial prohibitin (PHB) complex is essential for mitochondrial homeostasis, yet its depletion produces opposite effects on lifespan: shortening it in wild-type C. elegans but extending it in insulin/IGF-1 receptor daf-2 mutants, which show an attenuated mitochondrial unfolded protein response (UPRmt). To ide...
Sergio Gordillo-García, Jesus Fernandez-Abascal, Blanca Hernando-Rodríguez et al.
· Cell Reports · 0 citations