Reprogramming tumor-associated macrophages via ID3 mRNA delivery for enhanced immunotherapy in pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) features a profoundly immunosuppressive tumor microenvironment dominated by tumor-associated macrophages (TAMs), which facilitate immune evasion and compromise immunotherapeutic efficacy. The interaction between signal regulatory protein α (SIRPα) on macrophages and cluster of di...