Author

Eric Cascales

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Open access Sep 2026

A type VI secretion ADP-ribosyltransferase Rhs toxin selectively modifies charged tRNAThr(GGU) anticodon loops to block ACC codon decoding

Abstract The type VI secretion system (T6SS) is a sophisticated machine that uses a contractile mechanism to deliver antibacterial toxins into neighboring cells, hence participating to interbacterial competition and pathogenesis. Here, we characterize the T6SS-associated rearrangement hotspot RhsF polymorphic toxin fro...

Maïalène Chabalier, Jonas B. Desjardins, J. Martinkus et al. · Nucleic Acids Research · 0 citations

Open access Sep 2026

Experimental evolution reveals genetic routes for adaptive loss of the antibacterial type VI secretion system.

This work combined experimental evolution with whole-genome sequencing and whole-genome sequencing identified two RfaH-binding ops elements within the sci1 cluster, revealing antitermination as a regulatory element of EAEC T6SS transcription, which is conserved among Enterobacteriaceae.

Boris Taillefer, Jonas B. Desjardins, Eric Cascales · Current Biology · 0 citations

Review Aug 2026

Structure and Function of the Type IX Secretion System for Protein Secretion and Cellular Motility.

Current knowledge on T9SS architecture and function is summarized, the embedded gliding machinery is described, and conceptual advances and open questions regarding the mechanisms, dynamics, and ecological implications of this unique system are highlighted.

Yaëlle Aouizerate, Thierry Doan, Eric Cascales · Annual Review of Microbiolog... · 0 citations