Proteostasis, the cellular network that governs protein synthesis, folding, trafficking, and degradation, is essential for maintaining cellular and organismal homeostasis. This review series highlights the breadth and impact of European research in the field of proteostasis, spanning fundamental mechanisms, organelle‐s...
PROteolysis TArgeting Chimeras (PROTACs) are bifunctional molecules designed to induce targeted protein degradation by forming a transient ternary complex between an E3 ubiquitin ligase and a protein of interest (POI), leading to the E3‐mediated ubiquitination of the POI and its subsequent proteasomal degradation. Alth...
Sébastien Sueron, S. J. Mahdizadeh, Eric Chevet et al.· ChemMedChem· 0 citations
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