Eric E. Peterson

AZGP1 deficiency promotes chronic kidney fibrosis in aging mice.

OBJECTIVES Chronic kidney disease (CKD) affects 10-14% of the global population and is a leading cause of death. A hallmark of CKD is renal fibrosis, characterized by excessive extracellular matrix deposition. Although our understanding of fibrogenic mechanisms has advanced, effective antifibrotic therapies are lacking...