Author

Eric Largy

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Open access Sep 2026

Native Hydrogen/Deuterium Exchange Ion Mobility Mass Spectrometry of Structured DNA Oligonucleotides

Hydrogen/deuterium exchange coupled to mass spectrometry (HDX/MS) is a powerful technique to probe nucleic acid secondary structures and dynamics, but its ability to resolve conformers with identical masses remains limited. To overcome this challenge, we integrated ion mobility spectrometry (IMS) into our native HDX/MS...

Matthieu Ranz, Romane Guisiano, Eric Largy et al. · bioRxiv · 0 citations

Open access Jul 2026

Dibenzoacridinium derivatives: a new class of G-quadruplex ligands with anti-HIV-1 properties

The design, synthesis, and biophysical characterization of a novel class of G4-stabilizing ligands based on a positively charged dibenzoacridinium (DBA) core are reported, identifying DBAs as a new class of G-quadruplex ligands with anti-HIV properties.

Aman Kabbara, C. Buré, A. Guédin et al. · RSC Medicinal Chemistry · 0 citations