Pathological cardiac fibrosis and hypertrophy, key contributors to adverse remodeling that drives heart failure (HF), are not adequately targeted by current therapies. We identified tRNA-Asp-GTC-3′tDR, an ischemia-induced tRNA-derived small RNA (tDR), as an endogenous regulator of both remodeling processes across cardi...
Tian Hao, Jin Li, Kaushik V. Amancherla et al.· bioRxiv· 0 citations
It is shown that paediatric CKMD proteomic signatures predict cardiometabolic disease outcomes in adulthood, support an early origin of CKMD disease liability embedded in the human proteome in children, underscoring the value of precision prevention to forestall metabolic disease long before its clinical manifestation.
Joshua M. Landman, Heather M. Highland, A. Perry et al.· Nature Metabolism· 0 citations
Using spatial transcriptomics on longitudinal human cardiac biopsies, Amancherla, Oill and colleagues reveal marked cellular and molecular heterogeneity in transplanted hearts undergoing rejection, identify gene expression profiles linked to therapy response and outcomes, and show that acute rejection signatures are as...
Kaushik V. Amancherla, A. M. Taravella Oill, Xavier Bledsoe et al.· Nature Cardiovascular Resear...· 1 citation
A lipidome-wide GWAS of 830 lipid species in 2,287 Hispanic/Latino participants and predictive modeling across omics layers provided a genetic landscape of lipid metabolism in a highly burdened population and highlights the challenges in predicting lipid abundance.
Wanying Zhu, Hung-Hsin Chen, H. Highland et al.· HGG advances· 0 citations
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