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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Erica Dube

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3 papers indexed here

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Jul 2026

Abstract B046: A first-in-class Pin1 degrader provides robust PKPD response and efficacy in PDAC models

The prolyl isomerase Pin1 is a critical regulator of protein conformation and is frequently overexpressed across a spectrum of human malignancies. Its enzymatic activity is essential for stabilizing numerous oncogenic client proteins while promoting the turnover of key tumor suppressors, thereby driving neoplasti...

Morgan B. O'Shea, Guosen B. Ye, Melvyn B. Chow et al. · 0 citations
Jul 2026

Abstract B042: Clinical development and mechanism of action of LRK-4189, a first-in-class degrader of the lipid kinase PIP4K2C

Cancer cells maintain their fitness by developing survival adaptations that foster escape from intrinsic and extrinsic mechanisms of cell death in conditions of stress. Phosphatidylinositol 5-phosphate 4-kinase, type II, gamma (PIP4K2C) is a lipid kinase associated with poor outcomes in multiple tumors including...

Krista Goodman, Eva B. d'Hennezel, Morgan B. O'Shea et al. · 0 citations
Jul 2026

Abstract PR011: A first-in-class Pin1 degrader provides robust PKPD response and efficacy in PDAC models

The prolyl isomerase Pin1 is a critical regulator of protein conformation and is frequently overexpressed across a spectrum of human malignancies. Its enzymatic activity is essential for stabilizing numerous oncogenic client proteins while promoting the turnover of key tumor suppressors, thereby driving neoplasti...

Morgan B. O'Shea, Guosen B. Ye, Melvyn B. Chow et al. · 0 citations

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