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Erica Kim Man Lee

Hong Kong Baptist University

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Open access Aug 2026

Dynamism and evolvability in nucleic acid enzymes

It is proposed that threose nucleic acid (TNA), a genetic polymer that is more conformationally restricted than DNA, may be evolutionarily constrained by its preorganized backbone, and the rigid TNA backbone limits adaptability.

Erica Kim Man Lee, John C. Chaput · 0 citations

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