Author

Erica Stuart

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Open access Sep 2026

PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication

Mutations in the PRNP gene, which encodes the prion protein (PrP), cause genetic prion disease. However, how PRNP mutations lead to spontaneous prion formation remains poorly understood. Building off the observation that expression of mutant bank vole PrP (BVPrP) in mice causes spontaneous prion disease, we sought to i...

Genki Amano, H. Arshad, Surabhi Mehra et al. · bioRxiv · 0 citations

Open access Aug 2026

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Abstract Conformationally distinct “strains” of α‐synuclein aggregates are believed to contribute to the clinical and pathological diversity observed among synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease. Cases of MSA can be classified into two distinct subtypes: the cerebellar variant,...

Heather H. C. Lau, N. R. G. Silver, Surabhi Mehra et al. · Brain Pathology · 0 citations