Open access
Oct 2026
A selectivity filter in Tim17 mediates intramitochondrial protein sorting
Mitochondria import hundreds of proteins into the matrix and the inner membrane (IM). The translocase of the IM of mitochondria (TIM23 complex) sorts these proteins using topogenic signals in their structure and directs them into the matrix or inserts them into the IM. How these signals are deciphered is unknown. Her...
Annika Egeler, Sanjoy Paul, Rosario Valenti et al.
· Nature Communications · 0 citations