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Author

Erika Morrone

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Open access Sep 2026

Mapping the N/OFQ(1−13)-NH2 Address Domain to Identify G Protein-Biased NOP Receptor Agonists

The nociceptin/orphanin FQ peptide receptor (NOP) couples to G proteins and β-arrestins, but how the peptide address domain influences transducer preference remains unclear. We synthesized ninety N/OFQ(1−13)-NH2 analogues with acylated lysine-based or related non-natural residues at positions 5−13 and evaluated NOP−G...

Giulio Meneguzzo, Erika Morrone, Daniele Scarpa et al. · 0 citations

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