Open access
Aug 2026
Mitigating Bias in Health-Related Quality of Life (HRQoL) Estimation Due to Missing Data: A Simulation-Based Study Evaluating Imputation Methods
A preliminary policy is developed that could be used for HTA submissions, if the missingness pattern is not known and missingness ≤5%, that suggests MICE-based techniques are used as the base case for missingness >5%, and delta-PMM used as a sensitivity analysis when data are not MCAR.
Joe W. E. Moss, N. Hansell, Erin Barker et al.
· Health Economics and Policy · 0 citations