A Practical Review of Technical Barriers and Solutions on Mass Spectrometry-Based Multi-Attribute Method (MAM) in Biotherapeutics
The multi-attribute method (MAM) is a liquid chromatography–mass spectrometry (LC–MS) platform that combines site-specific quantitation of critical quality attributes (CQAs) with non-targeted new peak detection (NPD) in a single workflow, and can consolidate several conventional chromatographic and electrophoretic assa...