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Oct 2026
Chronic inflammation is increasingly recognized as a shared feature across neuropsychiatric, neurodegenerative, metabolic, oncologic, and post-infectious disorders, yet treatments mainly target downstream effects. Evidence suggests dysregulated glucocorticoid receptor (GR; encoded by NR3C1) signaling may regulate infla...
R. Slayden, R. Tjalkens, Neil D. Theise et al.
· Frontiers in Pharmacology · 0 citations
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Open access
Oct 2026
It is shown that loss of microglial PS1 shifts microglia toward a transcriptional and signaling state that enhances NMDA receptor-dependent synaptic activity and improves memory, demonstrating that microglial molecular programs can directly modulate neuronal excitability.
Paula da Silva Frost, C. Martínez, Alon Millet et al.
· Journal of Neuroscience · 0 citations
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