The aryl hydrocarbon signaling pathway in the ovary changes throughout reproductive aging and in response to a mixture of phthalates over time in mice.
Phthalates are plasticizers and solvents used in numerous consumer products. Exposure to a phthalate mixture (Mix) alters estrous cyclicity, fertility indices, ovarian follicle dynamics, and steroidogenesis. In cultured antral follicles, phthalates alter the aryl hydrocarbon receptor (AHR) pathway, which is known for e...