Review
Open access
Aug 2026
Crosstalk between UPR and mitochondria: The Triad of ER-Mitochondria Contacts, Ca²⁺, and ROS.
Three major drivers of coupling mitochondrial function to UPR signaling are analyzed, including enhanced ERMCs, IP3R-mediated Ca²⁺ transfer from the ER to mitochondria, and bidirectional ROS/H₂O₂ exchange between the two organelles.
Ester Zito, G. Hajnóczky
· Pharmacological Research · 1 citation