Systematic Reclassification of Variants of Uncertain Significance in a Clinical Nephrogenomics Program: Insights from the RAPIDS Collaboration
A nationwide nephrologist-led genetic testing program for suspected monogenic glomerular disease and unexplained chronic kidney disease was implemented across four tertiary hospitals in Singapore. Initial testing yielded a genetic diagnosis in 11.5% probands, while 77 (18.4%) harboured variants of uncertain signi...