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Author

Eugen Feist

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Open access Sep 2026

Differential regulation of SOCS signalling and immunoproteasome pathways by JAK inhibitors and TNF inhibitors in rheumatoid arthritis

Janus kinase (JAK) inhibitors and TNF inhibitors (TNFi) are established therapies in rheumatoid arthritis (RA), yet their differential effects on the JAK/STAT/SOCS/proteasome axis remain incompletely understood. This pilot study systematically characterised treatment-specific effects of baricitinib, tofacitinib, and TN...

K. Ghannam, Linh Nguyen My, Christine Behrendt et al. · 0 citations
Open access Sep 2026

CAR T cells for HLA desensitization: a new era in kidney transplantation

In a recent study published in the New England Journal of Medicine , autologous CD19-and BCMA-directed chimeric antigen receptor (CAR) T-cell therapy was evaluated as a desensitization strategy in two highly sensitized kidney transplant candidates. 1 In this safety run-in cohort of an ongoing phase I clinical trial (NC...

P. Mertens, Eugen Feist, D. Mougiakakos · 0 citations

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